Month: June 2025

Does It Work and Is It Legal in the UK?

If you’ve been browsing TikTok, Instagram, or aesthetic forums lately, chances are you’ve come across the term “Yellow Bottle” — the nickname for a fat-dissolving injectable that’s gone viral, particularly among those looking for quick fixes for stubborn fat areas like the chin, jowls, bra rolls or lower belly pooch.

But what exactly is Yellow Bottle, does it really work, and more importantly, is it legal and safe to use in the UK?

What Is “Yellow Bottle”?

“Yellow Bottle” typically refers to Cabellut Yellow, a formulation of deoxycholic acid, sometimes combined with other lipolytic agents, that is widely used in aesthetic clinics across parts of Europe, Latin America, and Asia.

• It gets its nickname from the distinctive bright yellow tint of the solution.

• It’s a non-surgical fat-dissolving injectable, designed to break down localised fat deposits.

• Not a brand officially licensed in the UK or FDA-approved, but often used off-label by some practitioners.

 How Does It Work?

Yellow Bottle works similarly to other aqualysis/lipolysis injectables, such as Aqualyx or Kybella (FDA-approved in the US).

• The active ingredient, usually deoxycholic acid, disrupts the fat cell membrane, effectively “melting” the fat.

• The destroyed fat is then removed by the body’s lymphatic system over several weeks.

• Results can be noticeable after 1–3 sessions, depending on the area treated and the patient’s metabolism.

It’s typically used for:

• Double chin (submental fat)
• Jowls
• Upper arms
• Abdomen or waistline bulges
• Inner knees and bra fat

Why Has It Become So Popular?

A few reasons contribute to the recent hype:

1. Social Media Virality: Videos showing dramatic before-and-after results in just weeks have made Yellow Bottle go viral on TikTok and Instagram.

2. Non-Surgical Appeal: It’s marketed as a non-invasive alternative to liposuction, with minimal downtime.

3. Accessibility Abroad: In countries where it’s widely available, it’s relatively low-cost compared to traditional fat reduction options.

4. Small Area Targeting: Unlike surgical methods, Yellow Bottle is ideal for refining contour in areas where even diet and exercise may not help.

Is It Safe? And Is It Legal in the UK?

• Not MHRA-approved: Yellow Bottle is not officially licensed for use in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA).

• Not regulated like Aqualyx: Unlike Aqualyx, which has CE marking for use in Europe, many Yellow Bottle formulations are not traceable or consistent in ingredients, and their safety profile may not be adequately tested.

• Used off-label: Some practitioners may offer it off-label, but this raises serious questions about safety, sterility, training, and accountability.

• Risk of complications: Bruising, swelling, prolonged inflammation, or even fat necrosis are risks, especially if performed by untrained injectors or in non-clinical settings.

Are There Safer, Official Alternatives?

Yes. In the UK, patients looking for small fat removal have safer, medically regulated alternatives, such as:

• Aqualyx: CE-marked injectable fat-dissolving product widely used for body contouring by doctors and aesthetic nurses.

• DesoFace / DesoBody: Another lipolytic injection used for targeted areas with a regulated formulation.

• Vaser Lipo: For those looking for a one-off, more dramatic result, these are minimally invasive yet doctor-led procedures with excellent precision.

While Yellow Bottle has earned a reputation for being an easy fix for stubborn fat, the reality is more complex. Its popularity may stem from social media buzz and overseas availability, but in the UK, safety, regulation, and transparency matter more than ever.

Combining PRP (Platelet-Rich Plasma), exosomes, and polynucleotides as a multi-modal treatment for female hair loss and thinning represents an exciting and forward-thinking approach that targets the hair follicle environment from multiple biological angles. Here is a breakdown of how each component works, the rationale for their combination, and a suggested treatment protocol.

Overview of Each Modality

1. PRP (Platelet-Rich Plasma)

• Mechanism: Autologous growth factors (e.g., PDGF, TGF-β, VEGF) from platelets stimulate angiogenesis, dermal papilla activity, and prolong the anagen phase of hair growth.

• Use: Particularly effective in early-stage androgenetic alopecia (AGA) and telogen effluvium.

2. Exosomes

• Mechanism: Nano-sized extracellular vesicles derived from stem cells (typically MSCs) that carry mRNA, microRNA, cytokines, and growth factors.

• Use: Improve intercellular communication, reduce inflammation, and promote follicular regeneration and cellular proliferation.

3. Polynucleotides

• Mechanism: DNA fragments (often from salmon DNA) that promote tissue regeneration, reduce oxidative stress, and support fibroblast activation and hydration of the extracellular matrix.

• Use: Improve scalp health, enhance healing, and create a favourable microenvironment for hair regrowth.

Rationale for Combination Therapy

Combining these three offers:

• Multi-layered stimulation (cellular, molecular, extracellular matrix)

• Faster response times and longer-lasting results

• Improved outcomes in difficult cases like female pattern hair loss, where hormonal factors and chronic inflammation play a role.

 Suggested Protocol

Ideal Patient: Women with early to moderate androgenetic alopecia, postpartum thinning, or diffuse hair shedding (e.g., telogen effluvium).

Initial Phase (Weeks 0–12):

• Week 0: PRP + Exosomes injection (scalp mesotherapy style or microneedling)

• Week 2: Polynucleotide scalp injection or microinjection

• Week 4: PRP alone

• Week 6: Exosomes + PRP

• Week 8: PN injection

• Week 12: Evaluation and booster (depending on response)

Maintenance Phase (every 3–4 months):

• Alternating PRP + exosomes or PRP + PNs, depending on patient response and scalp condition.

Considerations

• Exosomes should be from a reputable source and thoroughly screened

• Polynucleotides should be non-immunogenic

• Pre-treatment Scalp Priming (microneedling or fractional laser) may improve uptake and results.

• Adjunct Therapies: Topical minoxidil, low-level laser therapy (LLLT), and hormonal evaluation (especially for PCOS or menopause-related thinning).

Clinical Evidence & Support

• PRP: Strong support from meta-analyses (Gentile et al., 2015–2022).

• Exosomes: Early clinical results and case series suggest improved density and thickness within 6–8 weeks.

• Polynucleotides: Increasingly studied for scalp applications; positive findings in tissue regeneration and hydration improve hair density.

• This regenerative combination represents a next-gen, non-surgical approach to female hair restoration. By addressing follicular ageing, inflammation, and poor scalp vascularity simultaneously, it offers a highly tailored, effective, and well-tolerated protocol. particularly important for women who often respond less predictably to monotherapies.

 

Lipedema is a chronic condition characterised by an abnormal accumulation of fat, primarily in the legs and sometimes the arms, often accompanied by pain and sensitivity.

There is no cure for lipedema but several conservative treatments may help manage symptoms and improve quality of life. Here are some common conservative treatments:

1. Compression Therapy: Wearing compression garments, such as stockings or sleeves, can help reduce swelling, improve circulation, and provide support to the affected areas.

2. Lymphatic Drainage (LD): This specialised form of massage is designed to encourage lymphatic drainage, which can help reduce swelling and discomfort associated with lipoedema. It is best to choose a therapist with a deep understanding of this condition for the best therapy and support. Automated devices such as Pulsio have made home therapy more accessible and affordable. Dry Body brushing is also recommended to stimulate lymphatic flow.

3. Exercise: Low-impact exercises, such as swimming, walking, and gentle cycling, can help improve circulation, strengthen muscles, and promote overall health. It’s important to choose activities that are enjoyable and manageable.

4. Dietary Changes: While diet alone cannot cure lipoedema, a balanced diet can help manage weight and reduce inflammation. Some people find that a DNA-based, low-carb or anti-inflammatory diet is beneficial. Nutritionists who have studied and are experienced with lipoedema are best placed to

5. Weight Management: Maintaining a healthy weight can help alleviate some symptoms and reduce the progression of lipoedema. This may involve working with a doctor or nutritionist.

6. Pain Management: Over-the-counter pain relievers or prescription medications may be used to help manage pain and discomfort associated with lipoedema.

7. Physiotherapy: An experienced physiotherapist well versed in lipoedema can develop a personalised exercise program and provide education on proper body mechanics to promote mobility and function.

8. Support Groups and Counselling: Connecting with others who have lipoedema can provide emotional support and helpful tips for managing the condition.

9. Skin Care: Maintaining healthy skin through proper hygiene and moisturising with pure and organic shea butter or similar can help prevent complications, such as infections.

10. Educating Yourself and Others: Understanding lipoedema and educating family and friends can help create a supportive environment for managing the condition and your mental well-being. Always consult with a doctor with experience in lipedema for a personalised treatment plan tailored to your individual needs and circumstances.

Struggling with wrinkly knees can be a blow to your confidence, especially in your favourite outfits. While it’s a natural part of ageing, there are practical ways to smooth and strengthen your knee skin. From non-surgical treatments to everyday skincare tips, our guide covers all your options for restoring supple knees. Ready to say goodbye to ‘kninkles’? Keep reading.

Key Takeaways

• Collagen and elastin depletion with age contributes to wrinkles around the knees, but non-invasive treatments like microneedling, radiofrequency, and light therapies can stimulate production and smooth skin.
• Customised skincare routines tailored to individual needs are critical for knee rejuvenation, focusing on moisturising, exfoliating, and incorporating nutrient-rich foods for skin health.
• Combining different non-surgical treatments, such as injectable fillers, laser therapies, and PDO threads, can create customised solutions to effectively address knee wrinkles and sagging skin.

Understanding Wrinkly Knees: Causes and Concerns

Knee wrinkles, or ‘kninkles’, can become quite a concern as we age. Often, the culprit behind this is frequent stress on the knee area, such as regular kneeling, which leads to more pronounced wrinkles due to the repetitive stretching of the skin. As we get older, our skin, including that around our knees, naturally loses its elasticity, leading to sagging and wrinkles.

But why do we need to worry about wrinkly knees? Besides the obvious aesthetic concerns, wrinkles can also indicate skin health issues. A greater understanding of the causes and concerns linked to ‘kninkles’ can guide us towards effective treatments and preventative measures.

The Role of Collagen and Elastin in Knee Skin Health

Collagen and elastin, the vital proteins that uphold our skin’s elasticity and structure, contribute significantly to the smoothness and firmness of our knee skin. However, as we age, the natural production of these proteins decreases, leading to a loss of skin elasticity and structure. This manifests as sagging skin and wrinkles around our knees.

Encouragingly, treatments targeting collagen and elastin production can reduce age-related changes in our knee skin, thereby providing a smoother, firmer look.

Boosting Collagen Production Non-Invasively

When it comes to non-invasive procedures for enhancing collagen production, microneedling with PRP, radiofrequency, and light therapies stand out. For instance, Morpheus8 technologies utilise radiofrequency to heat the underlying skin tissues, stimulating new collagen formation. This leads to tighter, smoother skin.

Additionally, red light therapy can stimulate collagen growth, reduce wrinkles, and improve skin elasticity. There are options available for professional use, making it a popular choice for those seeking non-invasive treatments to enhance their knee skin health.

Enhancing Elastin Through Ultrasound Treatments

Upping the ante in non-invasive treatments, we have ultrasound. Treatments like Thermage FLX employ radiofrequency technology to heat skin deeply, stimulating new collagen formation and tightening existing collagen. This effectively treats wrinkles on the knees, resulting in firmer and more elastic skin with little to no downtime.

While generally safe, Thermage FLX treatments should be administered by trained professionals, as they can have side effects such as redness, swelling, or tenderness. However, patient feedback indicates visible improvements in skin firmness and a lifted appearance following these skin tightening treatments, showcasing the efficacy of radiofrequency in enhancing skin elasticity over time.

Personalised Skincare Regimens for Knee Rejuvenation

A personalised skincare routine tailored to one’s specific skin type can significantly aid knee rejuvenation. This should start with a basic regimen that includes a cleanser, an exfoliant, and a moisturiser. Implementing good skincare practices such as exfoliation and moisturising is key to preventing and minimising knee wrinkles. Hydrated skin responds better to being stretched; alongside internal hydration, using a hydrating topical cream can help maintain the skin’s moisture barrier, vital for knee rejuvenation.

Enhancing your skincare routine with toner post-cleansing, antioxidant serums, masks for specific concerns, and boosters for targeted care can offer benefits such as smoother skin, soothed redness, improved enlarged pores appearance, brighter skin, and faded signs of ageing. Incorporating foods high in antioxidants, healthy fats, and essential nutrients in your diet can also support skin health and aid in the prevention and reduction of wrinkles.

The concluding step requires trial and observation of skin reactions to fine-tune the amount, approach, and regularity of application to best meet your skin’s needs, as there are many factors that can influence the outcome. For further information, please refer to the provided guidelines.

Ablative Lasers

Ablative lasers, such as Erbium YAG and fractional CO2 lasers, offer another non-surgical solution for smoother, more youthful-looking skin. These lasers work by providing laser treatment that removes micro-layers of skin and stimulates cell renewal and collagen production. These non-surgical cosmetic procedures improve the appearance of deep wrinkles, providing smoother, more youthful-looking skin.

In addition to these, intense pulsed light (IPL) is used to treat sun spots and uneven skin texture. Its intense light stimulates more collagen and elastin, further enhancing the skin’s appearance.

Injectable Fillers: A Volumising Solution

Injectable fillers provide a volumising solution to knee wrinkles. Some options include:

• Radiesse
• Sculptra
• Neauvia’s Hydrodeluxe
• Profhilo Body Dermal fillers

These fillers often contain Hyaluronic acid, which helps to retain moisture and support collagen production, thereby adding volume and smoothing wrinkles in areas like the knees.

In addition to Hyaluronic acid-based fillers, other injectables like Sculptra and Lanluma have been used to stimulate collagen production and improve skin firmness around the knees. If results from Hyaluronic acid-based filler injections are unsatisfactory or side effects occur, the filler can be dissolved with a reversal agent called Hyaluronidase.

Lifestyle Adjustments to Prevent Further Wrinkling

Adopting a healthy lifestyle plays a significant role in averting additional knee wrinkling. This includes maintaining a healthy weight and strengthening the muscles around the knee through exercises, both of which can provide firmer support for the skin and help reduce the appearance of wrinkles.

To safeguard the skin and ward off new wrinkles, here are some tips:

• Employ sunscreen with a high SPF
• Don protective attire
• Maintain hydration through adequate fluid intake and consumption of water-rich foods
• Incorporate anti-inflammatory and antioxidant-rich foods into your diet to improve skin elasticity and promote collagen production in the bloodstream.

When to Consider Professional Consultation

Professional consultations are key in deciding the most suitable treatment plan and guaranteeing patient safety. These consultations are a critical phase where accurate diagnoses are formed, ensuring that the potential treatment outcomes are clearly outlined. Attentive listening and thorough information gathering during the consultation process are integral to proper diagnosis and patient safety. They help prevent misdiagnosis and associated risks.

Patients can enhance the quality of clinical consultations by:

• Being adequately prepared
• Ensuring clarity on discussions
• Bringing support if necessary
• Enquiring about test purposes, treatment options, side effects, and treatment timelines during the consultation

These steps can provide patients with a comprehensive understanding of their care.

Tailoring Your Treatment Plan: Combining Techniques

Combining different non-surgical procedures can lead to tailored treatments that effectively address specific skin concerns, such as wrinkles and sagging skin. For instance, laser therapy can be combined with chemical peels, or fillers can be combined with microneedling. Patient feedback indicates that combining Thermage FLX with other treatments like Hydrodeluxe dermal fillers enhances skin tightness and overall rejuvenation.

Personalised treatment plans minimise side effects and complications by considering the individual physiology and medical history of the client. A comprehensive initial consultation that encompasses the client’s:

• Medical history
• Current health status
• Lifestyle habits
• Particular goals and expectations

Understanding each individual’s needs is essential for customising the treatment plan to effectively restore volume.

PDO threads

PDO threads offer a non-surgical option to lift sagging skin and tighten it around the knees. They address skin sagging and wrinkles by inserting threads that stimulate collagen production, leading to firmer and more youthful-looking knee skin.

The threads used in this procedure are made of Polydioxanone (PDO), a biodegradable synthetic polymer that is absorbed by the body naturally, promoting collagen stimulation. They not only lift the skin but also stimulate the production of elastin and hyaluronic acid, which are essential for maintaining skin elasticity and hydration.

The insertion of PDO threads into the skin is a cosmetic procedure done using thin needles or cannulas after marking and applying local anaesthesia to the targeted area, making it minimally invasive with little discomfort.

Summary

There are numerous non-surgical solutions available to smooth and rejuvenate wrinkly knees, from boosting collagen production to implementing personalised skincare regimens, and from undergoing ablative laser treatments to receiving injectable fillers. Lifestyle adjustments and professional consultations also play crucial roles in ensuring the success of these treatments. While ‘kninkles’ might be a natural part of ageing, they don’t have to be a permanent fixture on your body. With the right care and treatment, you can confidently show off your knees again.

Frequently Asked Questions

How do I get rid of Crepey skin on my knees?

To get rid of crepey skin on your knees, consult a dermatologist for the best treatment options, which may include OTC products with retinol, prescriptions, radiofrequency, laser, ultrasound, fillers, or surgery. Additionally, using products with glycerin or hyaluronic acid can help improve the appearance of crepey skin by keeping it hydrated and plump.

How do you tone up saggy knees?

To tone up saggy knees, focus on targeting the quadriceps in the thighs through exercises such as lunges, squats, step-ups, and machine leg extensions. These exercises can help improve muscle tone and reduce the appearance of droopy knees.

Is Thermage FLX effective?

Yes, Thermage FLX is considered effective for tightening loose, saggy skin, and it is the latest and fourth generation of the device, offering improved results and faster, more comfortable treatments.

Are there lifestyle adjustments that can help prevent further knee wrinkling?

Yes, maintaining a healthy weight, strengthening the knee muscles through exercises, using high SPF sunscreen, wearing protective clothing, staying hydrated, and consuming anti-inflammatory and antioxidant-rich foods can all help prevent further knee wrinkling.

Hair loss is a common worry for men, but what many people don’t realise is that this is an issue many women experience as well. The average scalp has approximately 100,000 hairs and it’s natural for them to fall out after growing for two to six years, only to be replaced with new hair. However, discovering that the new hair simply isn’t growing back in, or at the very least, is no longer as full and luscious as it once was, can send many women into a panic. Since our hair is often the root of self-image, the thought of it thinning out can have a detrimental effect on our confidence and appearance. Fortunately, there are many plausible, affordable and effective options that can treat hair thinning for women. Wigs do not have to be your next hairstyle.

 

Way More Common Than You Think.

With all the hair treatments, heat products and extensive salon visits that many women enjoy, each strand is put through some intense procedures. Many of them basically strip each strand of their natural minerals, oils and overall health. This is likely the cause of hair thinning in women, becoming such a big concern for many people. You certainly are not alone. Hair breakage, thinning and loss is more common than we think, and can happen to women of all ages. Recent studies conducted by the American Hair Association stated that women make up approximately 40% of all reported hair thinning and loss conditions.

You Can Regain Your Confidence

One of the first things that seems to go when you notice your hair thinning out is your confidence. It can completely change your mood for the worse. The mere thought of having to wear a wig or no longer being able to style your hair as you please can be truly detrimental to the way you feel about yourself. The good news is that with the wide selection of hair thinning treatments for women, you can completely change your mood for the better as well.

Hair loss can be divided into two different categories. The first one is scarring, which is when the hair follicle is essentially destroyed. The second is non-scarring, which is when the hair is significantly damaged, but the scalp still has some room for restoration and repair. The latter is usually the category many women fall into as relaxers, colour treatments, heat products, ponytails and braids are common causes for this kind of hair loss. However, many other factors can contribute to hair loss in women.

 

Possible Causes of Hair Loss.

While the products that many women use on their hair are a major contributor to hair loss, some other things can trigger your hair follicles to stop producing new strands. Diet, extreme stress, hormone imbalances and genetics are to name a few, and can all be the cause of what you likely refer to as ‘the root of all evil’. Health conditions such as an iron deficiency, anaemia or a low thyroid can trigger hair loss as well. Toxic exposure to things such as mercury and arsenic can also cause hair loss, as well as environmental pollutants. Determining the cause of your hair thinning will allow you to pick from many of the incredibly effective hair thinning treatments available for women.

 

Treatment Options.

Treatment for hair loss in women can be as simple as taking nutritional supplements, changing your diet or giving your hair a serious break from chemical treatments and hot iron products. However, for more serious cases of hair thinning, the options are vast and generally much more rewarding as well.

Medicine is one option. Regaine (Minoxidil 5%) is an FDA-approved product for female pattern hair loss. Just one treatment a day can slow or stop hair loss in its tracks, while also encouraging healthy hair to start growing again. However, only a quarter of those who use this product experience hair regrowth, and when you stop using the product, the benefits are usually lost.

 

Laser Treatments (LLLT).

There are many laser treatments available that can effectively treat hair loss in women. Such devices emit low-energy lasers that can stimulate hair growth, giving your hair a fighting chance against becoming thinner. It is highly recommended that you only use laser treatments performed by highly trained professionals in order to reap the full benefits and to ensure safety, despite some hand-held devices being available for use at home. Generally, it takes approximately 2-4 months to see the results.

 

Hair Transplants in Women.

Hair transplants are also a viable option for women experiencing hair thinning or loss, whether by follicle by follicle (FUE) or by the strip method. The procedures consist of moving hair that comes from the permanent donor site to the thinning areas on the scalp. The actual cause of your hair thinning will determine whether this is the best option for you, as some women experience bald patches while others experience female pattern baldness, which causes the hair to thin all over.

These three options are some of the most popular and common procedures that women choose when experiencing hair thinning. Speaking to us will provide you with valuable information with specifics based on your condition. While many shampoos and beauty products claim to encourage hair growth, often they don’t provide results for women experiencing hair thinning or loss.