Profhilo London

By Dr Edwin Anthony, Lead Clinician, Contoura Medical · Treatments delivered by Nurse Rashmi Mehta · Last updated 19 October 2026

Profhilo is an injectable skin booster made from high-concentration Hyaluronic Acid that hydrates and remodels skin from within. It suits adults noticing dryness, crepiness or early laxity on the face or neck, and is usually given as two sessions about four weeks apart.

What it is and how it works

Profhilo is a "bio-remodelling" treatment rather than a filler. Each 2 mL syringe contains 32 mg of high molecular weight and 32 mg of low molecular weight Hyaluronic Acid, combined into what the manufacturer calls hybrid cooperative complexes. The gel is fluid enough to spread evenly beneath the skin instead of staying in one spot.

Once in place, it draws water into the skin and is thought to stimulate the cells that produce collagen and elastin. The result is skin that looks more hydrated, feels firmer and reflects light better, without changing your facial shape.

At Orovenza, Profhilo is delivered by Nurse Rashmi Mehta, our Aesthetic Nurse, at Langham Hospital, with medical oversight from Dr Edwin Anthony, Lead Clinician at Contoura Medical. For patients whose main concern is loss of support in the lower face and jawline, we may discuss Profhilo Structura at consultation, a newer version designed to work on the deeper layers of tissue.

Who it is best suited for

• Adults with dull, dehydrated or tired looking skin that has not responded to skincare alone.
• People with fine crepey lines on the cheeks, neck or lower face.
• Those noticing early laxity who are not ready for, or do not want, surgery.
• Patients after a natural change: you still look like yourself, just fresher.
• People whose skin feels thinner after weight loss, including those who have lost weight quickly.

Your treatment journey at Orovenza

1. Consultation: Nurse Rashmi examines your skin, takes a medical history and baseline photographs, and discusses whether Profhilo, Profhilo Structura or a different treatment fits your goals.
2. Plan: you receive a written plan with the areas to treat, session dates and your personal cost.
3. Treatment day: using the Bio Aesthetic Point (BAP) technique, the gel is placed at five set points on each side of the face. The appointment takes around 20 to 30 minutes.
4. Aftercare: you receive written guidance and a direct contact number. Your second session is usually booked about four weeks later.
5. Review: we compare your skin with your starting photographs and agree whether and when maintenance makes sense.

Results and how long they last

Most people notice skin looking more hydrated within a couple of weeks, with the fuller effect developing after the second session as collagen production responds. An open-label study in Aesthetic Plastic Surgery followed 30 women treated with two sessions four weeks apart using the BAP technique. At week 12, superficial skin hydration had increased by 21% and water loss through the skin had fallen by 21%, with no serious adverse events.

Results are not permanent because the body naturally breaks down Hyaluronic Acid over time. Many patients choose maintenance sessions every few months, and your practitioner will suggest timing based on how your skin responds rather than a fixed schedule.

Recovery and aftercare

• Expect small raised bumps at the injection points for up to 24 hours.
• Avoid make-up for 12 hours and keep the skin clean.
• Skip strenuous exercise, saunas, steam rooms and alcohol for 24 hours.
• Do not massage the treated areas unless advised.
• Delay facials, peels or laser treatment for around two weeks.
• Wear sunscreen daily to protect your results.

Safety, side effects and who should avoid it

• Common effects are temporary redness, swelling, tenderness and bruising at the injection points.
• Rarely, infection or an inflammatory reaction can occur, which is why we give a direct contact number and a review.
• Treatment is postponed during pregnancy or breastfeeding, with active skin infection such as a cold sore, or during illness.
• Tell us if you have an autoimmune condition, a history of severe allergy or take blood thinning medicines.
• We treat adults only, and the JCCP advises choosing a registered, properly trained practitioner for any injectable.

Profhilo compared with polynucleotides and dermal filler

How Orovenza compares

• Treatment in a hospital setting at Langham Hospital, 77 Hallam Street, Marylebone.
• Doctor-led, nurse-administered care, with treatment by Nurse Rashmi Mehta and clinical leadership from Dr Edwin Anthony (GMC registered).
• A consultation before every treatment, with baseline photographs so you can see real change.
• A fixed consultation fee that is not deducted from treatment prices, keeping costs clear.
• A review appointment after your course, and honest advice if another treatment would suit you better.

Related treatments

• Polynucleotides London
• Facial volumising London
• Morpheus8 Scale & Burst
• Anti-wrinkle injections London
• Orovenza treatments

If you would like to know whether Profhilo suits your skin, arrange a consultation at Langham Hospital or call 020 3890 1911. Consultation fees are fixed and are not deducted from treatment prices, and your practitioner confirms your personal treatment cost at consultation. Book a consultation

Frequently asked questions

Sources

1. Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High and Low Molecular Weight Hyaluronic Acid in Asian Patients, Aesthetic Plastic Surgery
2. IBSA launches Profhilo Structura, IBSA Group
3. Public safety advice, Joint Council for Cosmetic Practitioners (JCCP)